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Health: Cancer, Parkinson's, Alzheimer's are Metabolic Diseases

Below are talks from a number of people mentioned in Part 1 (The Scientific Establishment:  Dead Horses & White Elephants).

What all the people featured in these talks realise is that many of the big diseases that modern medicine has failed to treat (due to an over-emphasis on genetic research) are in fact epigenetic down-stream effects from impaired energy metabolism. Yes, "it's the energy, stupid!"

Below are some of the key points from "Metabolic Theory of Cancer Illuminates a New and Hopeful Path to a Cure"

Cancer when looked at through a metabolic lens has some interesting weaknesses that can be exploited.

  • The mitochondria in cancer cells are always massively impaired. 
  • Cancer cells produce energy through an anaerobic process via fermentation.
  • Cancer cells metabolise glucose and in the process produce lactic acid.
  • This lactic acid has to be expelled else the cancer cells will be killed and this is done via monocarboxylic acid transport.
  • 3-Bromopyruvate (see Pedersen, Young Ko et al) blocks monocarboxylic acid transport and thus the cancer cell's ability to shed this lactic acid ... "significantly, in subsequent experiments with rodents (19 animals with advanced cancer) Ko led a project in which 3BP was shown in a short treatment period to eradicate all (100%)"
  • In addition a calorie restricted ketogenic diet forces the body to produce ketones which healthy cells can use as fuel but cancer cells cannot. This kind of diet reduces blood sugar levels significantly, starving  cancer of its fuel.
  • Furthermore, diabetes drugs like Metformin which block the liver's ability to perform gluconeogenesis (a metabolic pathway that results in the generation of glucose from certain non-carbohydrate carbon substrates) provides an additional degrading of cancer cells' energy supply.


I hope the following talks provide as much illumination for you as they did for me.
 

Some promising recent research into effective therapies for: MND (i.e. ALS), Alzheimer's, Parkinson's & Cancer

Dr. D'Agostino is an Assistant Professor at the University of South Florida College Of Medicine, Molecular Pharmacology & Physiology where he develops and tests metabolic therapies for neurological disorders, cancer and wound healing.


 

Targeting Energy Metabolism in Brain Cancer

Dr Thomas Seyfried is Professor of Biology at Boston College whose research involves gene-environmental interactions in neurological and neurodegenerative diseases including epilepsy, autism, gangliosidoses, and brain cancer.


 

Metabolic Theory of Cancer Illuminates a New and Hopeful Path to a Cure

Travis Christofferson talks about the recent work of Pedersen and Young Ko, their work with 3-Bromopyruvate and the role of energy metabolism in cancer.


 

A Mitochondrial Etiology of Metabolic and Degenerative Diseases & Cancer

Douglas Wallace, Perelman School of Medicine at the University of Pennsylvania


 

Dr Rhonda Patrick: Nutrigenomics, Epigenetics, and Stress Tolerance

Dr Patrick earned her Ph.D. in biomedical science from the University of Tennessee and performed her graduate research work at St. Jude Children’s Research Hospital. She has done extensive research on aging, cancer and nutrition, and metabolism.

In this talk Dr Patrick explores the intersection between genetics, nutrition, and environment: how your diet, micronutrients, exercise, heat stress, and sleep can change the expression of your genes and how this has profound effects on the way your body functions and ages.