Health: Vitamin D - Master regulator of multi-role Serotonin (in both Brain and Gut)

In this fascinating conversation, Dr Rhonda Patrick outlines her recent research on the link between vitamin D, serotonin and autism. Vitamin D controls, at a very minimum, 5% of the human genome. This talk focuses on the role of vitamin D as a regulator of serotonin; damping serotonin's potentially over-active immune function in the gut, while activating serotonin's beneficial management functions (such as long term planning, impulse control, anxiety management and sensory gating) in the brain.

Serotonin plays a profound role in brain morphology and development and vitamin D regulates serotonin. So, if mum uses too much factor 50, that UVB doesn't make vitamin D and baby doesn't get enough serotonin and ... well, you can see where this is going.

Here's Dr Patrick to, as the Beach Boys might say, help us (Rhonda, help, help us Rhonda). We'll skip the pleasantries and get right into it:


Politics: A Tale of Two Currencies - Money & Oil (a.k.a. About Controller)

The world according to Controller is not a complicated one. Power is control and you can control people, states, and nation states by controlling the supply and nature of what they need: energy, money, food, water, medicine and information.

If you control the creation and supply of money, you can buy and control the rest. This infamous quote attributed to Mayer Amschel Rothschild is not hyperbole:

Permit me to issue and control the money of a nation, and I care not who makes its laws!

The documentary "How Big Oil Conquered the World" by James Corbett, illustrates the interplay between financial currency ("money") and energy currency ("oil") to create a powerful network with supranational control:

Given how much this explains, a naive soul may wonder why this isn't taught in school.

Ensuring this control does not get eroded requires the collusion of the state; which is why we have a military and surveillance industrial complex to police this system (sorry, "to keep you safe") and educational institutions that cannot define what money is, how it's created and who creates it (97% created out of thin air by private banks).

To make sure people remain clueless, we entertain a media (mostly owned by energy companies and populated by highly "educated" people) that spins these simple facts into meaningless riddles of mind-numbing nuance and obfuscation, while liberally using the term "conspiracy theory" to smear critical analysis of powerful interests. Ironically, this term is used without an understanding of its etymology; the term "conspiracy theory" leads us directly to a conspiracy fact (as it was shaped and propagated by the CIA through the U.S. media, in their directive "Countering Criticism of the Warren Commission Report").

Bilderberg 2016. The Ex-Conspiracy Meeting

It's a conspiracy fact that the very rich (those familiar names conspicuously absent from the Forbes rich list) have so much money that money is not the game; the game is power and power is control. This control requires multiple conspiracies (smaller than the ex-"conspiracy theory" above), which take place daily and are called "meetings".

The main aim of Controller is to provide as much understanding of this system and its effects, in as little time as possible. For this reason we don't post that often, but when we or others can get to the heart of the matter and lay out in a concise and straightforward manner how this system and its components actually function (in the real world), then we post it on Controller.

Politics: The High Priests of Money and their Holy Books

"Modern banking was developed in the United Kingdom in the 17th century and the legal facts are very clear but not very well known. Banks do not take deposits and banks do not lend money. That is a fact." -- Richard Werner

Mainstream economists are the clergy of finance; the high priests of this peculiar religion pontificate in grand temples we call Central Banks. Their role is to shroud politically motivated economic decisions in a complex, mumbo jumbo mythology, designed at once to justify policies that enrich and consolidate the money power, while simultaneously propagating the belief that their actions are founded on well established, scientifically robust, theories and models.

Fortunately, since the financial crisis of 2008, a brighter light has been shone on the credo of mainstream economics. How much longer the high priests' invocations from this sacred canon will continue to awe and mesmerise is debatable, what is not debatable is that almost all economics taught today is an intellectual fraud and has no basis in reality. If you doubt this to be true, please enjoy the following talk given by Richard Werner to the Russian Academy of Sciences in Moscow on "the Central Bank issue".   

There's a stark beauty in the way Mr Werner destroys, in simple, unambiguous language, the entire facade of dominant economic theory and in doing so reveals the rather ugly forces and motivations it was constructed to obscure.

The truth always has a markedly identifiable character: a lack of nuance and a simplicity without oversimplification.

Here's Mr Werner:

NOTE: The whole talk is worth watching and Richard Werner begins his talk at around 12 mins.
For brevity we begin at approximately 24 mins, 12 minutes into his talk.

Health: Cancer, Parkinson's, Alzheimer's are Metabolic Diseases

Below are talks from a number of people mentioned in Part 1 (The Scientific Establishment:  Dead Horses & White Elephants).

What all the people featured in these talks realise is that many of the big diseases that modern medicine has failed to treat (due to an over-emphasis on genetic research) are in fact epigenetic down-stream effects from impaired energy metabolism. Yes, "it's the energy, stupid!"

Below are some of the key points from "Metabolic Theory of Cancer Illuminates a New and Hopeful Path to a Cure"

Cancer when looked at through a metabolic lens has some interesting weaknesses that can be exploited.

  • The mitochondria in cancer cells are always massively impaired. 
  • Cancer cells produce energy through an anaerobic process via fermentation.
  • Cancer cells metabolise glucose and in the process produce lactic acid.
  • This lactic acid has to be expelled else the cancer cells will be killed and this is done via monocarboxylic acid transport.
  • 3-Bromopyruvate (see Pedersen, Young Ko et al) blocks monocarboxylic acid transport and thus the cancer cell's ability to shed this lactic acid ... "significantly, in subsequent experiments with rodents (19 animals with advanced cancer) Ko led a project in which 3BP was shown in a short treatment period to eradicate all (100%)"
  • In addition a calorie restricted ketogenic diet forces the body to produce ketones which healthy cells can use as fuel but cancer cells cannot. This kind of diet reduces blood sugar levels significantly, starving  cancer of its fuel.
  • Furthermore, diabetes drugs like Metformin which block the liver's ability to perform gluconeogenesis (a metabolic pathway that results in the generation of glucose from certain non-carbohydrate carbon substrates) provides an additional degrading of cancer cells' energy supply.

I hope the following talks provide as much illumination for you as they did for me.

Some promising recent research into effective therapies for: MND (i.e. ALS), Alzheimer's, Parkinson's & Cancer

Dr. D'Agostino is an Assistant Professor at the University of South Florida College Of Medicine, Molecular Pharmacology & Physiology where he develops and tests metabolic therapies for neurological disorders, cancer and wound healing.


Targeting Energy Metabolism in Brain Cancer

Dr Thomas Seyfried is Professor of Biology at Boston College whose research involves gene-environmental interactions in neurological and neurodegenerative diseases including epilepsy, autism, gangliosidoses, and brain cancer.


Metabolic Theory of Cancer Illuminates a New and Hopeful Path to a Cure

Travis Christofferson talks about the recent work of Pedersen and Young Ko, their work with 3-Bromopyruvate and the role of energy metabolism in cancer.


A Mitochondrial Etiology of Metabolic and Degenerative Diseases & Cancer

Douglas Wallace, Perelman School of Medicine at the University of Pennsylvania


Dr Rhonda Patrick: Nutrigenomics, Epigenetics, and Stress Tolerance

Dr Patrick earned her Ph.D. in biomedical science from the University of Tennessee and performed her graduate research work at St. Jude Children’s Research Hospital. She has done extensive research on aging, cancer and nutrition, and metabolism.

In this talk Dr Patrick explores the intersection between genetics, nutrition, and environment: how your diet, micronutrients, exercise, heat stress, and sleep can change the expression of your genes and how this has profound effects on the way your body functions and ages.

Health: The Scientific Establishment - Dead Horses & White Elephants

The accompanying post, "Cancer, Parkinson's, Alzheimer's are Metabolic Diseases" features a series of talks by pioneers in the field of energy metabolism and the associated pathologies arising from its dysfunction. Their  research and discoveries are leading to a "backdoor" revolution in treatments for diseases that, so far have thwarted the modern western medical establishment. In this post we'll look at the obstacles that slow such progress.

"Thomas Kuhn pointed out that even very careful scientists take in the world through a lens of prior concepts, or engage in “theory-laden observation.” Science is driven by ideas to start with, and our engagement with the world is based on this active lens of ideas. Sometimes we do change our conceptual filters [a “paradigm shift”]."   - David Kaiser on the legacy of Thomas Kuhn


Q. What does modern medicine have in common with cosmology?

With so much money, will and effort directed to finding cures for diseases such as cancer, Parkinson's and Alzheimer's, we need to ask why we've failed so badly? To answer this question, we need to understand how a wrong idea can become an  entrenched doctrine and in the process turn true pioneers into heretics and thwart genuine progress.

To do this, it's helpful to wander across domains. So let's have a look at two fiercely defended doctrines that have birthed myriad theoretical models that don't appear to be having the kinds of success originally promised :

  1. In cosmology, the concordance, hot big bang, expanding universe model (spawning theoretical models predicting: dark matter, dark energy, inflation etc.)
  2. In western medicine, the idea that genetic mutation is the root cause of cancer and many neurodegenerative diseases.

Four steps to nowhere good

How did these ideas take hold? Here's a generalised snapshot of the process:

Step 1:  Genuine scientific discovery:

  • Cosmology: Hubble's redshift velocity-distance relation, i.e. Hubble's Law (1929)
  • Modern Medicine:  The discovery of the double helical structure of the DNA molecule in 1953 by Francis Crick and James Watson

Step 2:  Theoretical models are then built atop these discoveries and in the process assumptions beyond the scope of the original discovery are then added (examples: The big bang, inflation, dark matter etc ... and in medicine - the somatic mutation theory of cancer).

Step 3:  Money flows into these fields and an entire army of researchers, hardware and infrastructure develops into an ecosystem devoted to further discovery.

Step 4:  Now livelihoods, reputations and even institutions are at stake, and any opposing theories must be fiercely attacked and their proponents beaten down and sometimes ostracised.

The Costs

This is how, in terms of cosmology enormous sums are spent in search of theoretical red-herrings like dark matter and dark energy (e.g. CERN) and complete distain is reserved for heretics like Halton Arp, the Burbidges, the Electric Universe proponents and Plasma Cosmologists, while all the time the evidence builds and builds in their favour, until hopefully there's a capitulation and enlightenment prevails.  Here the costs can be measured in terms of money, effort, and progress. 

In the case of modern medicine, billions and billions are spent in search of a noble (or perhaps Nobel) cure for cancer (see the 2 billion GBP London Cancer Hub), Parkinson's, Alzheimer's etc.  while the "heretics" featured in Part 2 of this post, like Thomas Seyfried, Young Ko, Dominic D'Agostino and Doug Wallace are persistently frustrated, either with funding, review board bureaucracy, the constant battle against the prevailing entrenched doctrine, sheer ignorance or a combination of all of these. 

When it comes to medicine, the costs are similar to those of cosmology, but one has to add human suffering to the balance sheet. Millions of people will have suffered greatly and died prematurely because of a rigid adherence to an idea - and that burden will sit on the consciences of those too proud, too insecure and too conflicted to entertain new and sometimes, as in the case of cancer, old ideas (see Otto Warburg).

Progress in a topsy-turvy world

Modern cosmology and medicine, for the reasons outlined above (but fundamentally due to entrenched interests), have ceased to be centres of scientific enquiry. You'll notice we've still not found any dark matter and there are structures in the universe that took longer to form than the age of the universe itself (go figure), while cancer rates continue to grow and cancer treatments remain medieval and ineffective: namely, the slash (surgery), burn (radiotherapy) and poison (chemotherapy) method we currently, with no sense of irony, call "the standard of care". 

Modern medicine has no cure for cancer or the list of neurodegenerative diseases whose spectre haunts all who approach later life. In addition, the big hope (fuelled by the prevailing somatic mutation theory of cancer), the "Cancer Genome Project" which was supposed to unlock the hidden secrets of this mysterious disease has instead radiated enormous amounts of noise, but no clear signal (as I've stated before, if you like surprises, a bad theoretical model is an indispensable tool).

On the other hand, the pharmaceutical industry has treatments for everything! There's plenty of financial incentive to treat; there's a countervailing, disincentive to cure. Afterall, what fiduciarily responsible pharmaceutical CEO wants their revenue stream interrupted by a clean bill of health?

Finally, what is most upsetting, is that very often the kinds of medical intervention being studied, trialled and expounded by these pioneers, do not slash, burn or poison, instead they are generally  benign (first do no harm?) and many are profoundly beneficial for not only the sick but also for those who wish to remain well. Yet, the medical establishment puts up the kinds of barricades one might expect if they were promoting mustard gas as a treatment. Yet, chemotherapy drugs (whose development was founded upon mustard gas) can travel unmolested through the review process as though these carcinogenic agents were god's own multivitamin.

It's surely a strange and topsy-turvy world we live in.

Part 2 - Cancer, Parkinson's, Alzheimer's are Metabolic Diseases (Promising Research into Effective Therapies for Cancer, ALS, Alzheimer's, Parkinson's)